Abstract
Effective management of diabetes relies on the frequent monitoring of blood glucose concentrations. The current approach of blood sampling and glucose concentration determination in vitro) presents many problems. Therefore, there is a drive for the development of non-invasive and continuous monitoring of glucose concentrations. The use of implanted glucose fluorescent sensors represents a promising approach. Due to its strong interaction with diol moieties, the boronic acid group often plays a critical role in the design of such glucose sensors. This paper reviews the progress in this area during the last ten years.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alcohols / chemistry
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Biosensing Techniques / methods*
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Blood Glucose / analysis*
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Boron Compounds / chemistry
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Boronic Acids / chemistry*
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Contact Lenses
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Diabetes Mellitus / blood
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Electrons
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Fluorescence Resonance Energy Transfer
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Fluorescent Dyes / chemistry*
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Glucose / analysis
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Humans
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Molecular Structure
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Monitoring, Physiologic / methods
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Monosaccharides / chemistry
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Oxidation-Reduction
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Water / chemistry
Substances
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Alcohols
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Blood Glucose
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Boron Compounds
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Boronic Acids
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Fluorescent Dyes
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Monosaccharides
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Water
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Glucose