Abstract
The synthesis and biological evaluation of some novel thiazolofluorenones, thiazolofluorenes and thiazoloanthraquinones, substituted with amino side-chains are described. These polyheterocyclic compounds have been synthesized via the corresponding imino-1,2,3-dithiazoles. Their cytotoxic activity and their eventual selective effect on a phase of the cell cycle were evaluated in vitro, using the murine lymphocytic L1210 leukaemia cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthraquinones / chemical synthesis
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Anthraquinones / chemistry
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Anthraquinones / pharmacology
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Cell Cycle / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Drug Screening Assays, Antitumor
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Fluorenes / chemical synthesis*
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Fluorenes / chemistry
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Fluorenes / pharmacology*
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In Vitro Techniques
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Leukemia L1210 / drug therapy
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Leukemia L1210 / pathology
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Mice
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Molecular Structure
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Structure-Activity Relationship