Peptide-cleaving catalyst selective for peptide deformylase

Pil Seok Chae; Myoung-Soon Kim; Chul-Seung Jeung; Seong Du Lee; Hwangseo Park; Sangyoub Lee; Junghun Suh

doi:10.1021/ja044043h

Peptide-cleaving catalyst selective for peptide deformylase

J Am Chem Soc. 2005 Mar 2;127(8):2396-7. doi: 10.1021/ja044043h.

Authors

Pil Seok Chae¹, Myoung-Soon Kim, Chul-Seung Jeung, Seong Du Lee, Hwangseo Park, Sangyoub Lee, Junghun Suh

Affiliation

¹ Department of Chemistry, Seoul National University, Seoul 151-747, Korea.

PMID: 15724986
DOI: 10.1021/ja044043h

Abstract

A peptide-cleaving catalyst selective for peptide deformylase (PDF) was obtained from a library containing about 15 000 catalyst candidates. The catalyst cleaved the polypeptide backbone of PDF at Gln(152)-Arg(153). Docking simulations suggested multiple modes of interactions in the complex formed between the catalyst and PDF.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemistry*
Amidohydrolases / chemistry*
Amidohydrolases / metabolism
Catalysis
Cobalt / chemistry*
Models, Molecular
Organometallic Compounds / chemistry*
Protein Conformation
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

Amides
Organometallic Compounds
cyclencobalt(III)
Cobalt
Amidohydrolases
peptide deformylase