Non-multifactorial neural tube defects

Am J Med Genet C Semin Med Genet. 2005 May 15;135C(1):69-76. doi: 10.1002/ajmg.c.30055.

Abstract

Although most neural tube defects (anencephaly, spina bifida) occur as isolated malformations, a substantial proportion are attributable to chromosome anomalies, known teratogens, or component manifestations of multiple anomaly syndromes. This review describes known chromosome alterations and the candidate genes residing in the altered region, as well as syndromes associated with neural tube defects and causative genes, if known.

Publication types

  • Review

MeSH terms

  • Abnormalities, Multiple / genetics
  • Animals
  • Chromosome Aberrations*
  • Genetic Predisposition to Disease*
  • Nerve Tissue Proteins / genetics*
  • Neural Tube Defects / genetics*
  • Risk Factors
  • Syndrome

Substances

  • Nerve Tissue Proteins