Abstract
Neuronal leucine-rich repeat proteins (NLRRs) are type I transmembrane proteins and expressed in neuronal tissues, but their function remains unknown. Here, we describe the identification and characterization of a new member of the NLRR family, NLRR4, and its potential role in long-lasting memory. We generated NLRR4-deficient (NLRR4(-/-)) mice and found that they showed impaired memory retention. In hippocampus-dependent learning tasks, NLRR4(-/-) mice were able to learn and maintain the memories for one day but unable to retain the memories for four days after learning. In contrast, in a hippocampus-independent task, NLRR4(-/-) mice were able to retain the memory normally for at least seven days. These results suggest that NLRR4 plays a key role in hippocampus-dependent long-lasting memory.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / metabolism
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Brain / physiopathology
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Cloning, Molecular
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Cues
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Fear / physiology
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Gene Deletion
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Hippocampus / metabolism
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Hippocampus / physiology*
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Hippocampus / physiopathology
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Long-Term Potentiation / physiology
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Maze Learning / physiology
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Membrane Proteins / chemistry
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Membrane Proteins / deficiency
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Membrane Proteins / genetics*
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Membrane Proteins / metabolism*
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Memory / physiology*
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Mice
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Mice, Inbred C57BL
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Mice, Inbred ICR
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / deficiency
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Nerve Tissue Proteins / genetics*
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Nerve Tissue Proteins / metabolism*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Synaptic Transmission / physiology
Substances
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Membrane Proteins
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NLRR4 protein, mouse
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Nerve Tissue Proteins
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RNA, Messenger