Abstract
A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Drug Screening Assays, Antitumor
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Ethers
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Humans
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Inhibitory Concentration 50
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Oximes
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Pyrazoles / chemical synthesis*
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Pyrazoles / pharmacology
Substances
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Antineoplastic Agents
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Ethers
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Oximes
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Pyrazoles