Abstract
We have previously shown that the leader peptide (p14) of the Env-precursor of mouse mammary tumor virus is translocated into the nucleoli of murine T cell lymphomas that harbor this virus. Using a polyclonal antibody against recombinant p14, we show here that p14 is also localized to the nucleoli of murine mammary carcinomas and some human breast cancer samples. Affinity purification studies define a number of proteins, mostly nucleolar, that bind p14. Taken together, these findings point towards a more general involvement of p14 in lymphomagenesis and mammary carcinogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Viral / biosynthesis
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Breast Neoplasms / metabolism
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Breast Neoplasms / virology*
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Cell Nucleolus / metabolism
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Cell Nucleolus / virology*
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Electrophoresis, Polyacrylamide Gel
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Humans
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Immunohistochemistry
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Lymphoma, T-Cell / metabolism
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Lymphoma, T-Cell / virology*
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Mammary Neoplasms, Experimental / metabolism*
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Mammary Neoplasms, Experimental / virology
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Mammary Tumor Virus, Mouse / metabolism*
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Mice
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Molecular Sequence Data
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Viral Envelope Proteins / biosynthesis
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Viral Envelope Proteins / immunology
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Viral Envelope Proteins / metabolism*
Substances
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Antibodies, Viral
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Viral Envelope Proteins