This study examined the effect of informational audiotapes on patients' self-care behaviors (SCBs) to manage chemotherapy side effects of fatigue, anxiety, and sleep disturbance. Seventy-one women with breast cancer participated. Thirty-three received audiotapes on SCBs to manage side effects. Three telephone interviews were conducted. Overall, women who received education demonstrated more SCBs, a wider range of SCBs, increased use of SCBs over time, and less anxiety. Nursing time for education in busy clinics is minimal. Patient anxiety in the clinic environment interferes with learning. Audiotapes are an effective tool for use at home, providing for teaching and reinforcement of patient education.