Elastic model for crimped collagen fibrils

J Biomech Eng. 2005 Aug;127(4):587-93. doi: 10.1115/1.1934145.

Abstract

A physiologic constitutive expression is presented in algorithmic format for the nonlinear elastic response of wavy collagen fibrils found in soft connective tissues. The model is based on the observation that crimped fibrils in a fascicle have a three-dimensional structure at the micron scale that we approximate as a helical spring. The symmetry of this wave form allows the force/displacement relationship derived from Castigliano's theorem to be solved in closed form: all integrals become analytic. Model predictions are in good agreement with experimental observations for mitral-valve chordae tendinece.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Chordae Tendineae / chemistry
  • Chordae Tendineae / physiology
  • Compressive Strength
  • Computer Simulation
  • Connective Tissue / chemistry*
  • Connective Tissue / physiology*
  • Elasticity
  • Fibrillar Collagens / analysis
  • Fibrillar Collagens / chemistry*
  • Fibrillar Collagens / metabolism*
  • Fibrillar Collagens / ultrastructure
  • Models, Biological*
  • Models, Chemical*
  • Stress, Mechanical
  • Structure-Activity Relationship
  • Weight-Bearing / physiology

Substances

  • Fibrillar Collagens