Abstract
Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Biphenyl Compounds / chemistry
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chloroform
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Hydrazines / chemistry
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In Vitro Techniques
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Lipid Peroxidation / drug effects
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Liver / drug effects
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Liver / metabolism
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Magnetic Resonance Spectroscopy
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Male
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Methanol
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Mice
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NADP / chemistry
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Oxidation-Reduction
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Phaeophyceae / chemistry*
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Picrates
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Quinones / chemistry*
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Rats
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Solvents
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Antineoplastic Agents
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Biphenyl Compounds
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Free Radical Scavengers
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Hydrazines
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Picrates
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Quinones
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Solvents
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NADP
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Chloroform
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1,1-diphenyl-2-picrylhydrazyl
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Methanol