Abstract
A Red Sea specimen of the marine sponge Hyrtios erectus was found to contain three new alkaloids, hyrtioerectines A-C (1-3). Hyrtioerectine A (1) possesses the carbon bond-linked moieties 6-hydroxy beta-carboline and 6-hydroxyindole. The structure elucidation of 1-3 was based on intensive study of their spectral data including 1D (1H and 13C) and 2D (1H-1H COSY, HOHAHA, NOESY, ROESY, HMQC, and HMBC) NMR, together with high-resolution mass spectra. Hyrtioerectines A-C were moderately cytotoxic.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Indian Ocean
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Indole Alkaloids
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hyrtioerectine A
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hyrtioerectine B
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hyrtioerectine C