Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials

Shengfu Chen; Jie Zheng; Lingyan Li; Shaoyi Jiang

doi:10.1021/ja054169u

Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials

J Am Chem Soc. 2005 Oct 19;127(41):14473-8. doi: 10.1021/ja054169u.

Authors

Shengfu Chen¹, Jie Zheng, Lingyan Li, Shaoyi Jiang

Affiliation

¹ Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.

PMID: 16218643
DOI: 10.1021/ja054169u

Abstract

In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adsorption
Animals
Cattle
Glycoproteins / chemistry*
Gold / chemistry
Humans
Microscopy, Atomic Force / methods
Molecular Structure
Particle Size
Phosphorylcholine / chemical synthesis
Phosphorylcholine / chemistry*
Serum Albumin, Bovine / chemistry*
Spectrometry, X-Ray Emission / methods
Static Electricity
Sulfhydryl Compounds / chemical synthesis
Sulfhydryl Compounds / chemistry
Surface Properties
Time Factors

Substances

Glycoproteins
Sulfhydryl Compounds
Phosphorylcholine
Serum Albumin, Bovine
Gold