Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)

J Biochem Mol Biol. 2002 Jan 31;35(1):61-6. doi: 10.5483/bmbrep.2002.35.1.061.

Abstract

The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-kappaB and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Cell Membrane / metabolism*
  • Cell Survival
  • Humans
  • Interleukin-1 / metabolism
  • MAP Kinase Signaling System
  • NF-kappa B / metabolism
  • Protein Binding
  • Protein Structure, Tertiary
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction
  • Structure-Activity Relationship
  • TNF Receptor-Associated Factor 1 / physiology
  • TNF Receptor-Associated Factor 2 / physiology
  • TNF Receptor-Associated Factor 3 / physiology
  • TNF Receptor-Associated Factor 4
  • TNF Receptor-Associated Factor 5 / physiology
  • TNF Receptor-Associated Factor 6 / physiology
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / physiology*

Substances

  • Interleukin-1
  • NF-kappa B
  • Receptors, Cell Surface
  • TNF Receptor-Associated Factor 1
  • TNF Receptor-Associated Factor 2
  • TNF Receptor-Associated Factor 3
  • TNF Receptor-Associated Factor 4
  • TNF Receptor-Associated Factor 5
  • TNF Receptor-Associated Factor 6
  • TRAF4 protein, human
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins