Palladium-catalyzed enantioselective conjugate addition of arylboronic acids

Francesca Gini; Bart Hessen; Adriaan J Minnaard

doi:10.1021/ol052222d

Palladium-catalyzed enantioselective conjugate addition of arylboronic acids

Org Lett. 2005 Nov 10;7(23):5309-12. doi: 10.1021/ol052222d.

Authors

Francesca Gini¹, Bart Hessen, Adriaan J Minnaard

Affiliation

¹ Department of Organic Chemistry and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

PMID: 16268565
DOI: 10.1021/ol052222d

Abstract

[reaction: see text] The first asymmetric palladium-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsaturated aldehydes, ketones, and esters is described. For cyclic substrates, excellent chemo-, regio-, and enantioselectivities are achieved when a Pd(O2CCF3)2/DuPHOS catalyst is applied.