Abstract
In a project to investigate plant derived natural products from the Liliaceae with activity against fast-growing strains of mycobacteria, we have identified two new metabolites from Chlorophytum inornatum. The active principle, a new homoisoflavanone (1) was identified as 3-(4'-methoxybenzyl)-7,8-methylenedioxy-chroman-4-one. The metabolite assigned as 7-(1'-hydroxyethyl)-2-(2''-hydroxyethyl)-3,4-dihydrobenzopyran (2) was characterised by extensive 1- and 2D NMR spectroscopy. The antimycobacterial activity of this plant was mainly due to the homoisoflavonoid which exhibited minimum inhibitory values ranging from 16-256 microg/ml against four strains of fast-growing mycobacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Asparagaceae / chemistry*
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Asparagaceae / metabolism
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Benzopyrans / chemistry*
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology*
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Isoflavones / chemistry*
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Isoflavones / isolation & purification
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Isoflavones / pharmacology*
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Liliaceae / chemistry*
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Liliaceae / metabolism
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Magnetic Resonance Spectroscopy / methods
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Magnetic Resonance Spectroscopy / standards
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Microbial Sensitivity Tests
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Molecular Conformation
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Mycobacterium / classification
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Mycobacterium / drug effects*
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Mycobacterium / growth & development
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Reference Standards
Substances
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3-(4'-methoxybenzyl)-7,8-methylenedioxychroman-4-one
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7-(1'-hydroxyethyl)-2-(2''-hydroxyethyl)-3,4-dihydrobenzopyran
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Anti-Bacterial Agents
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Benzopyrans
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Isoflavones