Abstract
Animal models are essential to study the pathogenesis of papillomavirus infection and develop strategies for treatment and prevention. This review details use of the cottontail rabbit papillomavirus (CRPV)-laboratory rabbit model. The protocols describe how to infect rabbits with CRPV DNA or CRPV virus to induce papillomas. They also describe the design and analysis of genetic pathogenesis experiments, prophylactic and therapeutic intervention experiments, and malignant progression experiments.
MeSH terms
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Animals
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Carcinoma, Squamous Cell / virology
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Cloning, Molecular / methods
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Cottontail rabbit papillomavirus / genetics
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Cottontail rabbit papillomavirus / growth & development
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Cottontail rabbit papillomavirus / pathogenicity*
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DNA, Viral / genetics
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DNA, Viral / isolation & purification
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Disease Models, Animal
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Genome, Viral
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Humans
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Papilloma / pathology*
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Papilloma / virology
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Papillomaviridae / genetics
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Papillomaviridae / growth & development
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Papillomaviridae / pathogenicity*
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Papillomavirus Infections / transmission*
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Polymerase Chain Reaction
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Rabbits
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Tumor Virus Infections / pathology