1-(5'-Fluoro-6'-hydroxy-5',6'-dihydrouracil-5'-yl)-5-fluorouracil, a novel N(1)-C(5)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic conditions

J Med Chem. 1992 Jul 10;35(14):2711-2. doi: 10.1021/jm00092a023.

Authors

S Nishimoto¹, H Hatta, H Ueshima, T Kagiya

Affiliation

¹ Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University, Japan.

PMID: 1635068
DOI: 10.1021/jm00092a023

No abstract available

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / pharmacology
Electrochemistry
Female
Fluorouracil / administration & dosage*
Fluorouracil / analogs & derivatives*
Fluorouracil / pharmacology
Fluorouracil / radiation effects
Mice
Mice, Inbred C3H
Prodrugs / pharmacology
Prodrugs / radiation effects*
Thymine / administration & dosage

Substances

Antineoplastic Agents
Prodrugs
1-(5'-fluoro-6'-hydroxy-5',6'-dihydrouracil-5'-yl)-5-fluorouracil
Thymine
Fluorouracil