Abstract
Twenty-three BK virus and JC virus DNA samples obtained from urine of pregnant women had almost exclusively archetypal transcriptional control regions. Rearrangements characteristic of laboratory strains are apparently not required for reactivation in humans. Unexpectedly, alignment shows that many elements identified previously in the BK virus enhancer are conserved in the JC virus archetype.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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BK Virus / genetics*
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Base Sequence
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DNA, Viral / genetics
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Enhancer Elements, Genetic
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Female
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Gene Rearrangement
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Humans
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JC Virus / genetics*
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Molecular Sequence Data
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Polymerase Chain Reaction
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Pregnancy
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Pregnancy Complications, Infectious / microbiology*
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Pregnancy Complications, Infectious / urine
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Promoter Regions, Genetic
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Regulatory Sequences, Nucleic Acid*
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Transcription, Genetic
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Tumor Virus Infections / microbiology*
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Tumor Virus Infections / urine
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Urine / microbiology