Abstract
NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / metabolism
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology*
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Biological Transport, Active
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Cloning, Molecular
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Drug Resistance, Bacterial / genetics
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Gene Expression Regulation, Bacterial
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Genes, Bacterial*
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Genes, Regulator*
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Microbial Sensitivity Tests
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Mutation
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Quinolones / metabolism
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RNA, Bacterial / analysis
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RNA, Messenger / analysis
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Repressor Proteins / genetics
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Repressor Proteins / physiology*
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Reverse Transcriptase Polymerase Chain Reaction
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Staphylococcus aureus / genetics
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Staphylococcus aureus / physiology*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Quinolones
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RNA, Bacterial
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RNA, Messenger
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Repressor Proteins