The objective of this study was to compare the effectiveness and comfort of Damon 2 brackets and conventional twin brackets during initial alignment. Sixty consecutive patients participated in a split mouth design. One side of the lower arch was bonded with the Damon 2 bracket and the other with a conventional twin bracket. The sides were alternated with each consecutive patient. The irregularity index (II) was measured for each half of the arch at baseline, at 10 weeks at the first archwire change, and at another 10 weeks at the second archwire change. Any difference in discomfort was assessed within the first few days of archwire placement and again at the first archwire change. Comfort on the lips, preferred look, and bracket failure rates were also recorded. The twin bracket was more uncomfortable with the initial archwire (P = .04). However, at 10 weeks, substantially more patients reported discomfort with the Damon 2 bracket when engaging the archwire (P = .004). At both archwire changes at 10 and 20 weeks (P = .001), the conventional bracket had achieved a lower II than the Damon 2 bracket by 0.2 mm, which is not clinically significant. Patients preferred the look of the twin bracket over the Damon 2 (P < .0005) and more Damon 2 brackets debonded during the study (P < .0005). The Damon 2 bracket was no better during initial alignment than a conventional bracket. Initially, the Damon 2 bracket was less painful, but it was substantially more painful when placing the second archwire and had a higher bracket failure rate.