Abstract
Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cell Survival / drug effects
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Dendrimers
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Dose-Response Relationship, Drug
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Drug Delivery Systems*
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Drug Screening Assays, Antitumor
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Gene Silencing*
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Humans
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Kinetics
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Molecular Structure
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Nanoparticles / chemistry
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Polyamines / chemistry*
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RNA, Small Interfering / chemistry*
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RNA, Small Interfering / pharmacology
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Structure-Activity Relationship
Substances
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Dendrimers
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PAMAM Starburst
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Polyamines
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RNA, Small Interfering