pH-induced release from P2VP-PEO block copolymer vesicles

Uwe Borchert; Ute Lipprandt; Matthias Bilang; Andrea Kimpfler; Anja Rank; Regine Peschka-Süss; Rolf Schubert; Peter Lindner; Stephan Förster

doi:10.1021/la060227t

pH-induced release from P2VP-PEO block copolymer vesicles

Langmuir. 2006 Jun 20;22(13):5843-7. doi: 10.1021/la060227t.

Authors

Uwe Borchert¹, Ute Lipprandt, Matthias Bilang, Andrea Kimpfler, Anja Rank, Regine Peschka-Süss, Rolf Schubert, Peter Lindner, Stephan Förster

Affiliation

¹ Institute of Physical Chemistry, University of Hamburg, D-20146 Hamburg, Germany.

PMID: 16768517
DOI: 10.1021/la060227t

Abstract

The pH-induced release of hydrophilic dyes from poly(2-vinylpyridine-b-ethylene oxide) (P2VP-PEO) block copolymer vesicles is investigated. The structure of the vesicles is characterized using small-angle neutron scattering (SANS) and cryo-electron microscopy (cryo-TEM). A decrease of the pH below 5 leads to protonation and dissolution of the poly-2-vinylpyridine blocks which induces rupture and dissolution of the vesicle membrane. Details of the rupture, dissolution, and release process are studied by fluorescence video microscopy, gel electrophoresis, and high-performance ultrafiltration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cryoelectron Microscopy
Hydrogen-Ion Concentration
Membranes, Artificial
Microscopy, Fluorescence
Microscopy, Video
Neutron Diffraction
Polyethylene Glycols / chemistry*
Polyvinyls / chemistry*

Substances

Membranes, Artificial
Polyvinyls
poly(2-vinylpyridine-block-ethylene oxide)
Polyethylene Glycols