Abstract
The bioassay-directed isolation of a marine brown alga, Ishige okamurae, afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV-1 reverse transcriptase and integrase with IC(50) values of 9.1 microM and 25.2 microM, respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HIV-1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / pharmacology
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HIV Integrase / drug effects*
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HIV Integrase Inhibitors / pharmacology*
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HIV Reverse Transcriptase / antagonists & inhibitors*
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Heterocyclic Compounds, 3-Ring / pharmacology*
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Phaeophyceae*
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Plant Extracts / pharmacology
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Protease Inhibitors / pharmacology*
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Reverse Transcriptase Inhibitors / pharmacology*
Substances
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Anti-HIV Agents
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HIV Integrase Inhibitors
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Heterocyclic Compounds, 3-Ring
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Plant Extracts
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Protease Inhibitors
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Reverse Transcriptase Inhibitors
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diphlorethohydroxycarmalol
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HIV Integrase
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HIV Reverse Transcriptase