Abstract
Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive oxygen species. In this paper, we describe the pharmacological properties of mitochondrial potassium channels and their modulation by channel inhibitors and potassium channel openers. We also discuss potential side effects of these substances.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Calcium / metabolism
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Humans
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Ion Channel Gating
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Membrane Potentials / drug effects
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Mitochondria / drug effects
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Mitochondria / physiology*
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Potassium Channel Blockers / pharmacology
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Potassium Channels / agonists
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Potassium Channels / physiology*
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Potassium Channels, Calcium-Activated / agonists
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Potassium Channels, Calcium-Activated / antagonists & inhibitors
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Potassium Channels, Voltage-Gated / agonists
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Potassium Channels, Voltage-Gated / antagonists & inhibitors
Substances
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Potassium Channel Blockers
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Potassium Channels
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Potassium Channels, Calcium-Activated
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Potassium Channels, Voltage-Gated
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Adenosine Triphosphate
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Calcium