The purpose of this study was to compare the sealing ability of gutta-percha and AH Plus sealer versus Resilon and Epiphany Resin Root Canal sealer using three different final irrigants with the fluid filtration model. There were 140 teeth prepared using a crown-down method to a size 50 file. The teeth were randomly divided into two groups: (A) GP and AH Plus and (B) Resilon and Epiphany. After removal of the smear layer each group was irrigated with either 5.25% NaOCl, 0.012% chlorhexidine (CHX), or 2% CHX for 10 minutes. Obturation was performed using the continuous wave of condensation. The teeth were stored for 20 days in 100% humidity before testing. Two-way ANOVA analysis indicated significantly less leakage (p < 0.05) using Resilon with Epiphany sealer compared to gutta-percha and AH Plus sealer. There was no statistical significance between any of the irrigants used for either obturation group.