Objective: To assess the association between the single nucleotide polymorphism of the insulin receptor (INSR) gene and polycystic ovary syndrome (PCOS) in a Korean population.
Design: Case-control study.
Setting: University-based hospital.
Patient(s): One hundred seventy-four patients with PCOS and 93 healthy women as controls.
Main outcome measure(s): Frequency of three genotypes for single nucleotide polymorphism found in exon 17 of INSR gene.
Result(s): The high frequency of the T allele was shown both in patient and control groups. The frequency of C allele, which known as a normal allele, was slightly higher in the patient group than in the control group.
Conclusion(s): The C/T polymorphism in exon 17 of the INSR gene is not associated with susceptibility of PCOS in a Korean population.