Secondary cutaneous effects of hydroxyurea: possible pathogenetic mechanisms

Elisa Zaccaria; Emanuele Cozzani; Aurora Parodi

doi:10.1080/09546630600780494

Secondary cutaneous effects of hydroxyurea: possible pathogenetic mechanisms

J Dermatolog Treat. 2006;17(3):176-8. doi: 10.1080/09546630600780494.

Authors

Elisa Zaccaria¹, Emanuele Cozzani, Aurora Parodi

Affiliation

¹ Di.S.E.M. Department of Endocrinological and Metabolic Science, Section of Dermatology, University of Genoa, Genoa, Italy.

PMID: 16854761
DOI: 10.1080/09546630600780494

Abstract

We report the case of a 73-year-old man who had been on hydroxyurea for essential thrombocythemia since 1988. After 12 years of treatment he developed a symmetrical dermatomyositis-like eruption together with a leg ulceration and five squamous cell carcinomas of the face. The possible pathogenetic mechanisms of these known side effects are discussed.

Publication types

Case Reports

MeSH terms

Aged
Arm / pathology
Diagnosis, Differential
Drug Eruptions / diagnosis*
Drug Eruptions / etiology
Drug Eruptions / pathology
Humans
Hydroxyurea / administration & dosage
Hydroxyurea / adverse effects
Hydroxyurea / therapeutic use*
Leg Ulcer / chemically induced
Leg Ulcer / diagnosis*
Leg Ulcer / pathology
Male
Nucleic Acid Synthesis Inhibitors / administration & dosage
Nucleic Acid Synthesis Inhibitors / adverse effects
Nucleic Acid Synthesis Inhibitors / therapeutic use*
Thrombocytopenia / drug therapy*

Substances

Nucleic Acid Synthesis Inhibitors
Hydroxyurea