Abstract
Prolonged consumption of ethanol significantly reduces the capacity of rat liver mitochondria to oxidize acetaldehyde. This is associated with decreased mitochondrial respiration with acetaldehyde as substrate. The reduced ability of mitochondria to metabolize acetaldehyde may explain the high levels of acetaldehyde in the blood of alcoholics, which in turn could promote the perpetuation of liver injury.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetaldehyde / blood
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Acetaldehyde / metabolism*
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Alcoholic Intoxication / metabolism*
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Animals
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Female
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Glutamate Dehydrogenase / metabolism
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Humans
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In Vitro Techniques
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Mitochondria, Liver / enzymology
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Mitochondria, Liver / metabolism*
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Models, Biological
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NAD / metabolism
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NADH, NADPH Oxidoreductases / metabolism
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Oxidation-Reduction
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Rats
Substances
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NAD
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Glutamate Dehydrogenase
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NADH, NADPH Oxidoreductases
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Acetaldehyde