Abstract
To explore the influence of binding to human parainfluenza virus type 1 (hPIV-1), a series of 4-O-substituted Neu5Ac2en derivatives 6a-e was synthesized and tested for their ability to inhibit hPIV-1 sialidase. Among compounds 6a-e, the 4-O-ethyl-Neu5Ac2en derivative 6b showed the most potent inhibitory activity (IC50 6.3 microM) against hPIV-1 sialidase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Humans
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Inhibitory Concentration 50
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N-Acetylneuraminic Acid / analogs & derivatives*
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N-Acetylneuraminic Acid / chemical synthesis
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N-Acetylneuraminic Acid / chemistry
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N-Acetylneuraminic Acid / pharmacology
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Neuraminidase / antagonists & inhibitors*
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Parainfluenza Virus 1, Human / drug effects
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Parainfluenza Virus 1, Human / enzymology*
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Respirovirus Infections / drug therapy
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Respirovirus Infections / enzymology
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Structure-Activity Relationship
Substances
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Antiviral Agents
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Enzyme Inhibitors
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2-deoxy-2,3-dehydro-N-acetylneuraminic acid
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Neuraminidase
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N-Acetylneuraminic Acid