An overview of permanent and semipermanent fillers

Plast Reconstr Surg. 2006 Sep;118(3 Suppl):7S-14S. doi: 10.1097/01.prs.0000234900.26676.0b.

Abstract

The demand for safe, effective, long-lasting, biocompatible dermal filler materials is increasing. Many products that include synthetic polymers and autologous tissue have emerged that attempt to meet these criteria. An overview of injectable permanent fillers, including ArteFill, Aquamid, and silicone, and semipermanent fillers, including Radiesse, Sculptra, and autologous fat, is presented. A discussion of their composition, histologic characteristics, antigenicity, U.S. Food and Drug Administration approval status, indications for use, efficacy, injection technique, and adverse effects is provided.

Publication types

  • Review

MeSH terms

  • Acrylic Resins / administration & dosage
  • Acrylic Resins / adverse effects
  • Acrylic Resins / therapeutic use
  • Adipose Tissue / transplantation
  • Animals
  • Biocompatible Materials / administration & dosage
  • Biocompatible Materials / adverse effects
  • Biocompatible Materials / therapeutic use*
  • Cattle
  • Cellulose / administration & dosage
  • Cellulose / adverse effects
  • Cellulose / therapeutic use
  • Durapatite / adverse effects
  • Durapatite / therapeutic use
  • Foreign-Body Reaction / etiology
  • Foreign-Body Reaction / prevention & control
  • Humans
  • Hydrogels / administration & dosage
  • Hydrogels / adverse effects
  • Hydrogels / therapeutic use
  • Injections, Subcutaneous
  • Lactic Acid / administration & dosage
  • Lactic Acid / adverse effects
  • Lactic Acid / therapeutic use
  • Mannitol / administration & dosage
  • Mannitol / adverse effects
  • Mannitol / therapeutic use
  • Microspheres
  • Plastic Surgery Procedures
  • Polymers / administration & dosage
  • Polymers / adverse effects
  • Polymers / therapeutic use
  • Polymethyl Methacrylate / adverse effects
  • Polymethyl Methacrylate / therapeutic use
  • Rejuvenation
  • Silicones / administration & dosage
  • Silicones / adverse effects
  • Silicones / therapeutic use
  • Skin Aging
  • Subcutaneous Tissue / pathology
  • Transplantation, Autologous

Substances

  • Acrylic Resins
  • Aquamid
  • Biocompatible Materials
  • Hydrogels
  • New-Fill
  • Polymers
  • Silicones
  • Lactic Acid
  • Mannitol
  • Cellulose
  • Polymethyl Methacrylate
  • Durapatite