Abstract
We demonstrated that not whole Mycobacterium tuberculosis but its particular antigens, hsp70(Mtb), hsp65(Mtb), and hsp16(Mtb), are present in lymph node tissues of patients with sarcoidosis (SA). hsp16(Mtb) occurs in the early stage of SA, whereas hsp70(Mtb) occurs in stage II of SA. hsp65(Mtb) is highly expressed in the capillary vessels in lymph node tissues in patients with SA.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Bacterial Proteins / metabolism*
-
Chaperonin 60
-
Chaperonins / metabolism*
-
HSP70 Heat-Shock Proteins / metabolism*
-
Heat-Shock Proteins / metabolism*
-
Humans
-
Lymph Nodes / metabolism*
-
Lymph Nodes / microbiology
-
Mycobacterium tuberculosis / metabolism
-
Mycobacterium tuberculosis / pathogenicity*
-
Sarcoidosis, Pulmonary / diagnosis*
-
Sarcoidosis, Pulmonary / microbiology
-
Tuberculosis / diagnosis*
-
Tuberculosis / microbiology
Substances
-
Bacterial Proteins
-
Chaperonin 60
-
HSP70 Heat-Shock Proteins
-
HSP70 protein, Mycobacterium tuberculosis
-
Heat-Shock Proteins
-
HspA protein, bacteria
-
heat-shock protein 65, Mycobacterium
-
Chaperonins