Synthesis of 2-vinylic indoles and derivatives via a Pd-catalyzed tandem coupling reaction

Aude Fayol; Yuan-Qing Fang; Mark Lautens

doi:10.1021/ol061374l

Synthesis of 2-vinylic indoles and derivatives via a Pd-catalyzed tandem coupling reaction

Org Lett. 2006 Sep 14;8(19):4203-6. doi: 10.1021/ol061374l.

Authors

Aude Fayol¹, Yuan-Qing Fang, Mark Lautens

Affiliation

¹ Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

PMID: 16956187
DOI: 10.1021/ol061374l

Abstract

A novel one-step synthesis of valuable 2-vinylic indoles and their tricycle derivatives is described. This reaction, which utilizes a gem-dibromovinyl unit as a readily available starting material, occurs via an efficient Pd-catalyzed tandem Buchwald-Hartwig/Heck reaction.