Abstract
The 3C protease from foot-and-mouth disease virus (FMDV 3C(pro)) is critical for viral pathogenesis, having vital roles in both the processing of the polyprotein precursor and RNA replication. Although recent structural and functional studies have revealed new insights into the mechanism and function of the enzyme, key questions remain that must be addressed before the potential of FMDV 3C(pro) as an antiviral drug target can be realised.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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3C Viral Proteases
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Animals
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Cysteine Endopeptidases / chemistry*
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Cysteine Endopeptidases / metabolism
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Foot-and-Mouth Disease / drug therapy
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Foot-and-Mouth Disease / enzymology
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Foot-and-Mouth Disease Virus / enzymology*
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Foot-and-Mouth Disease Virus / pathogenicity
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Protein Precursors / metabolism
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Protein Structure, Secondary
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Protein Structure, Tertiary
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RNA / biosynthesis
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RNA, Viral / biosynthesis
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Viral Proteins / antagonists & inhibitors
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Viral Proteins / chemistry*
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Viral Proteins / metabolism
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Virus Replication / physiology
Substances
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Protein Precursors
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RNA, Viral
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Viral Proteins
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RNA
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Cysteine Endopeptidases
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3C Viral Proteases