Abstract
The synthesis, structure, and biological evaluation of a series of novel rifamycin derivatives, Rifastures (RFA) with potent anti-tuberculosis activity are presented. Some of these derivatives showed higher in vitro activity than rifabutin and rifampicin against not only Mycobacterium tuberculosis strains but also against MAC and Mycobacterium kansasii.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antitubercular / chemical synthesis
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Antibiotics, Antitubercular / pharmacology*
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Drug Resistance, Microbial
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Microbial Sensitivity Tests
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Mycobacterium avium Complex / drug effects*
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Mycobacterium kansasii / drug effects*
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Mycobacterium tuberculosis / drug effects*
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Rifabutin / analogs & derivatives
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Rifabutin / chemical synthesis
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Rifabutin / pharmacology*
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Rifampin / pharmacology
Substances
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Antibiotics, Antitubercular
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Rifabutin
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Rifampin