Abstract
One gracilarioside and two gracilamides with unusual cyclopropane-containing alkyl chains were isolated from the red alga Gracilaria asiatica. Their structures were determined by spectroscopic methods and microscale chemical degradation. To our knowledge, no ceramides with a cyclopropane ring have been reported from marine organisms. These three compounds were mildly cytotoxic to the human A375-S2 melanoma cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / isolation & purification
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Antineoplastic Agents* / pharmacology
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Cell Line, Tumor
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Cyclopropanes* / chemistry
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Cyclopropanes* / isolation & purification
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Cyclopropanes* / pharmacology
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Drug Screening Assays, Antitumor
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Gracilaria / chemistry*
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Humans
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Marine Toxins / chemistry
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Marine Toxins / isolation & purification*
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Marine Toxins / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Antineoplastic Agents
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Cyclopropanes
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Marine Toxins
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gracilamide A
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gracilamide B
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gracilarioside