Abstract
One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, Thin Layer
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Drug Screening Assays, Antitumor
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Enzyme Inhibitors / pharmacology
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Glucosides / chemistry
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Glucosides / isolation & purification
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Plant Roots / chemistry
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Polygonum / chemistry*
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Spectrophotometry, Ultraviolet
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Stilbenes / chemistry*
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Stilbenes / isolation & purification
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Stilbenes / pharmacology
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Tetrazolium Salts
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Thiazoles
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
Substances
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Antineoplastic Agents, Phytogenic
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Enzyme Inhibitors
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Glucosides
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Stilbenes
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Tetrazolium Salts
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Thiazoles
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
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thiazolyl blue