Abstract
We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Antigens, Bacterial* / genetics
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Bacterial Outer Membrane Proteins* / genetics
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Borrelia burgdorferi / genetics
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Borrelia burgdorferi / growth & development*
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Borrelia burgdorferi / immunology*
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Gene Deletion
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Immunity, Innate / genetics
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Lyme Disease / immunology
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Lyme Disease / microbiology*
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Lyme Disease / transmission
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Mice
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Mice, Inbred C3H
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Skin Diseases, Bacterial / immunology
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Skin Diseases, Bacterial / microbiology
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Skin Diseases, Bacterial / transmission
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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OspC protein