Abstract
New bone formation on an RGD-containing oligopeptide-coated surface in vitro and in vivo was investigated. The surface showed two-fold higher osteoblastic cell adhesion and differentiation in vitro, and revealed statistically significant in vivo bone formation compared with the control (P < 0.05).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Adhesion / drug effects
-
Cell Line
-
Cell Proliferation / drug effects
-
Coated Materials, Biocompatible / administration & dosage
-
Coated Materials, Biocompatible / chemistry
-
Fibronectins / administration & dosage*
-
Fibronectins / chemistry*
-
Humans
-
Oligopeptides / administration & dosage*
-
Oligopeptides / chemistry*
-
Osteoblasts / cytology*
-
Osteoblasts / drug effects
-
Osteoblasts / physiology*
-
Osteogenesis / drug effects
-
Osteogenesis / physiology*
Substances
-
Coated Materials, Biocompatible
-
Fibronectins
-
Oligopeptides
-
arginyl-glycyl-aspartic acid