Abstract
Chemical investigation of the culture broth extracts of the marine-derived fungus Massarina sp. (strain CNT-016) has yielded two secondary metabolites, spiromassaritone (1) and massariphenone (2), as well as the previously reported fungal metabolites 6-epi-5'-hydroxy-mycosporulone (3) and enalin A (4). The structures of these compounds were established by a variety of one- and two-dimensional NMR experiments, while the relative configuration of spiromassaritone (1) was determined by X-ray crystallographic methods. The fungal strain was isolated as a sterile mycelium from an ocean mud sample and identified using ITS sequence analysis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Ascomycota / classification
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Ascomycota / metabolism*
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Benzene Derivatives / chemistry*
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Benzene Derivatives / isolation & purification
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Benzene Derivatives / metabolism
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Crystallography, X-Ray
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Cyclohexanones / chemistry*
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Cyclohexanones / isolation & purification
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Cyclohexanones / metabolism
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Ketones / chemistry*
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Ketones / isolation & purification
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Ketones / metabolism
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Models, Molecular
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Nuclear Magnetic Resonance, Biomolecular
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Phenols / chemistry*
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Phenols / isolation & purification
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Phenols / metabolism
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Phylogeny
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Spiro Compounds
Substances
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6-epi-5'-hydroxy-mycosporulone
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Benzene Derivatives
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Cyclohexanones
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Ketones
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Phenols
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Spiro Compounds
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enalin A
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massariphenone
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spiromassaritone