Abstract
The effects of the highly selective histamine H4 receptor antagonists JNJ7777120 and VUF6002 were investigated on the carrageenan-induced inflammation and thermal hyperalgesia in rats. JNJ7777120 (10 and 30 mg/kg, s.c.) and VUF6002 (10 mg/kg, s.c.) significantly reduced paw edema and hyperalgesia provoked by subplantar injection of carrageenan; the effect was evident against the early (2 h) phase of inflammation. An inactive analog of VUF6002, VUF6007 (10 mg/kg, s.c.) slightly aggravated paw edema, while leaving unaltered carrageenan-induced nociception. These findings indicate that histamine H4 receptors participate in the early phase of acute inflammation induced by carrageenan in rats, influencing both edema and thermal hyperalgesia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / pharmacology*
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Benzimidazoles / pharmacology*
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Carrageenan
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Disease Models, Animal
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Edema / metabolism
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Edema / prevention & control
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Histamine Antagonists / pharmacology*
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Hot Temperature
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Hyperalgesia / etiology
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Hyperalgesia / metabolism
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Hyperalgesia / prevention & control*
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Indoles / pharmacology*
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Inflammation / chemically induced
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Inflammation / complications
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Inflammation / metabolism
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Inflammation / prevention & control*
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Male
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Pain Measurement
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Piperazines / pharmacology*
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Rats
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Rats, Wistar
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Receptors, G-Protein-Coupled / antagonists & inhibitors*
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Receptors, G-Protein-Coupled / metabolism
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Receptors, Histamine / metabolism
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Receptors, Histamine H4
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Time Factors
Substances
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Analgesics
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Anti-Inflammatory Agents
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Benzimidazoles
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Histamine Antagonists
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Hrh4 protein, rat
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Indoles
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Piperazines
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Receptors, G-Protein-Coupled
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Receptors, Histamine
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Receptors, Histamine H4
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VUF 6002
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1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine
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Carrageenan