Abstract
A novel furanosteroid named 9-epi-viridiol (1), along with viridiol (2) and mevalonic acid (3), was isolated from Trichoderma virens. The structure of 1 was verified by combined spectroscopic data (COSY, HSQC, HMBC and NOESY) to be a C-9 epimer of viridiol. 9-epi-Viridiol exhibited cytotoxicity towards HeLa and KB cells with IC50 values of 19 and 50 microg mL(-1), respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Androstenediols / chemistry*
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Androstenediols / isolation & purification
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Androstenediols / pharmacology
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Formazans
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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KB Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Optical Rotation
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Spectrophotometry, Ultraviolet
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Stereoisomerism
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Tandem Mass Spectrometry
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Tetrazolium Salts
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Thailand
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Trichoderma / chemistry*
Substances
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Androstenediols
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Antineoplastic Agents
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Formazans
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Tetrazolium Salts
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MTT formazan
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viridiol