Abstract
Recent genetic evidence reveals additional salvage pathways for NAD(+) synthesis. In this issue, Belenky et al. (2007) report that nicotinamide riboside, a new NAD(+) precursor, regulates Sir2 deacetylase activity and life span in yeast. The ability of nicotinamide riboside to enhance life span does not depend on calorie restriction.
MeSH terms
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Aging / metabolism*
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Animals
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Histone Deacetylases / metabolism*
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Humans
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Longevity
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NAD / biosynthesis*
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Niacinamide / analogs & derivatives*
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Niacinamide / metabolism
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Niacinamide / pharmacology
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Pyridinium Compounds
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Saccharomyces cerevisiae / metabolism*
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Silent Information Regulator Proteins, Saccharomyces cerevisiae / metabolism*
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Sirtuin 2
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Sirtuins / metabolism*
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Vitamins / metabolism*
Substances
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Pyridinium Compounds
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Silent Information Regulator Proteins, Saccharomyces cerevisiae
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Vitamins
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nicotinamide-beta-riboside
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NAD
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Niacinamide
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SIR2 protein, S cerevisiae
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Sirtuin 2
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Sirtuins
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Histone Deacetylases