Vitamins and aging: pathways to NAD+ synthesis

Cell. 2007 May 4;129(3):453-4. doi: 10.1016/j.cell.2007.04.023.

Abstract

Recent genetic evidence reveals additional salvage pathways for NAD(+) synthesis. In this issue, Belenky et al. (2007) report that nicotinamide riboside, a new NAD(+) precursor, regulates Sir2 deacetylase activity and life span in yeast. The ability of nicotinamide riboside to enhance life span does not depend on calorie restriction.

Publication types

  • Comment

MeSH terms

  • Aging / metabolism*
  • Animals
  • Histone Deacetylases / metabolism*
  • Humans
  • Longevity
  • NAD / biosynthesis*
  • Niacinamide / analogs & derivatives*
  • Niacinamide / metabolism
  • Niacinamide / pharmacology
  • Pyridinium Compounds
  • Saccharomyces cerevisiae / metabolism*
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae / metabolism*
  • Sirtuin 2
  • Sirtuins / metabolism*
  • Vitamins / metabolism*

Substances

  • Pyridinium Compounds
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • Vitamins
  • nicotinamide-beta-riboside
  • NAD
  • Niacinamide
  • SIR2 protein, S cerevisiae
  • Sirtuin 2
  • Sirtuins
  • Histone Deacetylases