A methylation rendezvous: reader meets writers

Dev Cell. 2007 Jun;12(6):843-4. doi: 10.1016/j.devcel.2007.05.011.

Abstract

It is well established that two marks of silent chromatin, DNA methylation and histone H3 methylation at lysine 9, engage in an epigenetic conversation. In a recent issue of Genes & Development, Smallwood et al. (2007) report that the mammalian HP1 adaptor "translates" methylation information from histone to DNA, helping to cement epigenetic expression states.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Chromatin
  • Chromobox Protein Homolog 5
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Gene Silencing*
  • Histones / metabolism*
  • Humans
  • Lysine / metabolism*
  • Methylation*
  • Transcription, Genetic / genetics*

Substances

  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Histones
  • Chromobox Protein Homolog 5
  • Lysine