Selective effects of diallyl disulfide, a sulfane sulfur precursor, in the liver and Ehrlich ascites tumor cells

Eur J Pharmacol. 2007 Aug 13;569(1-2):1-7. doi: 10.1016/j.ejphar.2007.04.055. Epub 2007 May 22.

Abstract

The present in vivo studies demonstrated that diallyl disulfide (DADS), occurring in garlic, elevated hepatic sulfane sulfur level and activities of gamma-cystathionase and 3-mercaptopyruvate sulfotransferase in healthy mice but did not affect the hepatic glutathione level. DADS efficiently corrected the concentrations of glutathione and sulfane sulfur, and ameliorated gamma-cystathionase activity that had been lowered in the livers of Ehrlich ascites tumor-bearing mice. In Ehrlich ascites tumor cells, diallyl disulfide did not alter bound sulfane sulfur level, sulfotransferases activity or glutathione level. These data indicate that this compound is capable of acting efficiently and selectively only in the liver and can be used for hepatoprotection during chemotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allyl Compounds / chemistry
  • Allyl Compounds / metabolism
  • Allyl Compounds / pharmacology*
  • Animals
  • Carcinoma, Ehrlich Tumor / metabolism
  • Carcinoma, Ehrlich Tumor / pathology
  • Cell Line, Tumor
  • Cyanides / metabolism
  • Cystathionine gamma-Lyase / metabolism
  • Disulfides / chemistry
  • Disulfides / metabolism
  • Disulfides / pharmacology*
  • Dose-Response Relationship, Drug
  • Female
  • Garlic / chemistry*
  • Glutathione / metabolism
  • Liver / drug effects*
  • Liver / metabolism
  • Liver / pathology
  • Mice
  • Neoplasms, Experimental / metabolism
  • Neoplasms, Experimental / pathology
  • Neoplasms, Experimental / prevention & control
  • Protective Agents / metabolism
  • Protective Agents / pharmacology
  • Sulfhydryl Compounds / metabolism
  • Sulfides / chemistry
  • Sulfides / metabolism
  • Sulfides / pharmacology
  • Sulfur Compounds / metabolism
  • Sulfurtransferases / metabolism
  • Thiosulfate Sulfurtransferase / metabolism

Substances

  • Allyl Compounds
  • Cyanides
  • Disulfides
  • Protective Agents
  • Sulfhydryl Compounds
  • Sulfides
  • Sulfur Compounds
  • diallyl trisulfide
  • diallyl disulfide
  • allyl sulfide
  • Sulfurtransferases
  • Thiosulfate Sulfurtransferase
  • 3-mercaptopyruvate sulphurtransferase
  • Cystathionine gamma-Lyase
  • Glutathione
  • n-propyl disulfide