Abstract
Antimicrobial proteins (AMP) are endogenous, gene-encoded proteins, which are able to kill bacteria, fungi and viruses at micro- and nanomolar concentrations. The constitutive as well as inducible production of AMP provides a rapid first-line of defense against invading microorganisms. The significance of such ancient defense system is reflected by the wide distribution of AMP in the plant and animal kingdom. There is increasing evidence that AMP may play an important role in several infectious and inflammatory diseases such as atopic dermatitis, cystic fibrosis and Crohn's disease. In this review we aim to provide a short overview about the role of antimicrobial proteins in human diseases. In addition, the use and selective induction of AMP for the development of novel potential therapeutic strategies are addressed. The benefits and possible restrictions of AMP utilization as a new class of antibiotic compounds are discussed.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Anti-Infective Agents / metabolism
-
Anti-Infective Agents / pharmacology
-
Anti-Infective Agents / therapeutic use*
-
Anti-Inflammatory Agents, Non-Steroidal / metabolism
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
-
Cystic Fibrosis / drug therapy
-
Cystic Fibrosis / pathology
-
Cystic Fibrosis Transmembrane Conductance Regulator / pharmacology
-
Cystic Fibrosis Transmembrane Conductance Regulator / therapeutic use
-
Defensins / pharmacology
-
Defensins / therapeutic use
-
Gastrointestinal Diseases / drug therapy
-
Gastrointestinal Diseases / metabolism
-
Humans
-
Infections / drug therapy*
-
Inflammation / drug therapy*
-
Muramidase / chemistry
-
Muramidase / metabolism
-
Phagocytes / chemistry
-
Proteins / metabolism
-
Proteins / pharmacology
-
Proteins / therapeutic use*
-
Skin Diseases / drug therapy
-
Skin Diseases / pathology
Substances
-
Anti-Infective Agents
-
Anti-Inflammatory Agents, Non-Steroidal
-
Defensins
-
Proteins
-
Cystic Fibrosis Transmembrane Conductance Regulator
-
Muramidase