Abstract
Three alkoxyalkyl 2-carboxylate ester derivatives related to zanamivir were synthesized. All of the analogs of zanamivir modified at carboxylic moiety with alkoxyalkyl esters 1a-c showed higher activities than ribavirin on influenza A and B virus in the MDCK cells. Oral treatment or intraperitoneal administration of compound 1c showed significantly protective effects in mice infected with influenza A virus with low toxicities.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Administration, Oral
-
Animals
-
Cell Line
-
Disease Models, Animal
-
Dogs
-
Drug Design
-
Humans
-
Influenza A virus / metabolism*
-
Influenza Vaccines / chemistry
-
Influenza, Human / drug therapy*
-
Infusions, Parenteral
-
Inhibitory Concentration 50
-
Mice
-
Ribavirin / pharmacology
-
Zanamivir / analogs & derivatives
-
Zanamivir / chemical synthesis*
-
Zanamivir / chemistry
-
Zanamivir / pharmacology*
Substances
-
Influenza Vaccines
-
Ribavirin
-
Zanamivir