Abstract
Two new steroidal saponins, namely (25R)-5beta-spirostan-3-beta-ol 3-O-beta-D-galactopyranosyl-(1'''-->4'')-O-beta-D-galactopyranosyl-(1''-->3')-O-beta-D-glucopyranoside (2), and (25R)-5beta-spirostan-3-beta-ol 3-O-beta-D-galactopyranosyl-(1'''-->4'')-O-beta-D-glucopyranosyl-(1''-->3')-O-beta-D-glucopyranoside (3), together with six known constituents, have been isolated from the leaves of Dracaena ombet Kotschy & Peyr. (Dracaenaceae). The structures of the two saponins were established by chemical and physicochemical analyses, including FAB- and HR-ESI-MS and 2D NMR. The fraction rich in saponins showed significant analgesic and anti-inflammatory activities (at a high dose of 30 mg/kg b.w.) and non-significant antiulcer activities at the same doses.
MeSH terms
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Acetic Acid
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Administration, Oral
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Analgesics / administration & dosage
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Analgesics / chemistry
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Analgesics / pharmacology*
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Analgesics / therapeutic use
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / therapeutic use
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Carrageenan
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Dose-Response Relationship, Drug
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Dracaena*
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Edema / chemically induced
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Edema / prevention & control
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Indomethacin
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Male
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Mice
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Pain / chemically induced
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Pain / prevention & control
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Leaves
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Rats
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Rats, Sprague-Dawley
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Saponins / administration & dosage
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Saponins / pharmacology
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Saponins / therapeutic use
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Specific Pathogen-Free Organisms
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Stomach Ulcer / chemically induced
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Stomach Ulcer / prevention & control
Substances
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Analgesics
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Anti-Inflammatory Agents
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Plant Extracts
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Saponins
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Carrageenan
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Acetic Acid
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Indomethacin