Abstract
The first total synthesis of santiagonamine (1) is achieved in 12 steps from isovanillin. A palladium-catalyzed Ullmann cross-coupling reaction and a photocyclization are the key steps in the synthesis.
MeSH terms
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Alkaloids / chemical synthesis*
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Benzaldehydes / chemistry
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Berberis / chemistry
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Coumarins / chemical synthesis*
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Isoquinolines / chemical synthesis*
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Plants, Medicinal / chemistry
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Wound Healing
Substances
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Alkaloids
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Benzaldehydes
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Coumarins
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Isoquinolines
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santiagonamine
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isovanillin