Abstract
Four new ENT-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyses. in vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1-7.2 microM.
MeSH terms
-
Antineoplastic Agents, Phytogenic / administration & dosage
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Antineoplastic Agents, Phytogenic / therapeutic use
-
Cell Line, Tumor / drug effects
-
Diterpenes / administration & dosage
-
Diterpenes / pharmacology
-
Diterpenes / therapeutic use
-
Diterpenes, Clerodane / administration & dosage
-
Diterpenes, Clerodane / pharmacology*
-
Diterpenes, Clerodane / therapeutic use
-
Humans
-
Inhibitory Concentration 50
-
Phytotherapy*
-
Plant Components, Aerial
-
Scutellaria*
Substances
-
Antineoplastic Agents, Phytogenic
-
Diterpenes
-
Diterpenes, Clerodane