A novel ansamycin, naphthomycin K from Streptomyces sp

Chunhua Lu; Yuemao Shen

doi:10.1038/ja.2007.84

A novel ansamycin, naphthomycin K from Streptomyces sp

J Antibiot (Tokyo). 2007 Oct;60(10):649-53. doi: 10.1038/ja.2007.84.

Authors

Chunhua Lu¹, Yuemao Shen

Affiliation

¹ Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, School of Life Science, Xiamen University, Fujian, PR China.

PMID: 17965482
DOI: 10.1038/ja.2007.84

Abstract

One novel ansamycin, namely naphthomycin K, together with two known naphthomycins A and E, were isolated from the commensal strain Streptomyces sp. CS of the medicinal plant Maytenus hookeri. Their structures were elucidated by the analysis of NMR and MS data. Naphthomycin K showed evident cytotoxicity against P388 and A-549 cell lines, but no inhibitory activities against Staphylococcus aureus and Mycobacterium tuberculosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / isolation & purification
Antibiotics, Antineoplastic / pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Maytenus / chemistry
Microbial Sensitivity Tests
Molecular Conformation
Mycobacterium tuberculosis / drug effects
Naphthoquinones / isolation & purification
Naphthoquinones / pharmacology*
Rifabutin / chemistry
Spectrometry, Mass, Electrospray Ionization
Staphylococcus aureus / drug effects
Streptomyces / chemistry*

Substances

Antibiotics, Antineoplastic
Naphthoquinones
naphthomycin K
Rifabutin